Mechanical Properties of Arteries in Vivo

作者：Lysle H. Peterson, RODERICK E. JENSEN, John Roderick Parnell · 发表于：Circulation Research · 年份：1960 · DOI：10.1161/01.res.8.3.622 · 被引用次数：687 · 研究领域：Cardiovascular Health and Disease Prevention、Elasticity and Material Modeling、Cardiovascular Disease and Adiposity

Methods have been assembled permitting the simultaneous recording of intra-arterial pressure and arterial diameter with sufficient accuracy so that the mechanical properties of arteries in vivo, under physiologic conditions, can be derived. The analysis necessitates finding the relationships between 5 simultaneous variables; hence the data were recorded on magnetic tape and processed by analog and digital computer technics. Analysis of the data established the fact that the mechanical properties of arteries can be described by a linear, first-order differential equation whose coefficients can be defined as the moduli of elasticity and viscosity. Furthermore, the magnitudes of the coefficients were evaluated. The strain which the arteries undergo as a result of arterial pulse pressure variations is normally between 0.01 and 0.04, i.e., between 1 and 4 per cent change in circumference. The total strain associated with marked constriction and dilation does not usually exceed 10 per cent. Therefore, it is established that the circumferential motion of arteries may be characterized as small strain. The fact that the strain is effectively small is confirmed by analytical consideration, i.e., stress-strain relationships can be linearized under physiologic conditions without introducing significant error. The mass of the artery wall does not play a significant role in determining the mechanical behavior of the arteries and can therefore be neglected in any such considerations. The ha...