In vitro efficacy of sulbactam combined with ampicillin against anaerobic bacteria

作者：Hannah M. Wexler, Betty Harris, W T Carter, S M Finegold · 发表于：Antimicrobial Agents and Chemotherapy · 年份：1985 · DOI：10.1128/aac.27.5.876 · 被引用次数：65 · 研究领域：Bacterial Identification and Susceptibility Testing、Streptococcal Infections and Treatments、Antibiotic Use and Resistance

An ampicillin-sulbactam combination was compared with ampicillin alone, chloramphenicol, clindamycin, and metronidazole against 272 strains of anaerobic bacteria. Chloramphenicol and ampicillin-sulbactam were the most effective, inhibiting 98 to 99% of strains tested at breakpoint (16 micrograms/ml). The combination of sulbactam and ampicillin was much more effective than ampicillin alone against Bacteroides fragilis strains but did not differ substantially from ampicillin alone against Fusobacterium spp., gram-positive rods, and gram-positive cocci.