Insulin-Like Growth Factors: A Role in Growth Hormone Negative Feedback and Body Weight Regulation via Brain

作者：Gloria Shaffer Tannenbaum, Harvey J Guyda, Barry I. Posner · 发表于：Science · 年份：1983 · DOI：10.1126/science.6338593 · 被引用次数：362 · 研究领域：Growth Hormone and Insulin-like Growth Factors、Regulation of Appetite and Obesity、Diet and metabolism studies

Intracerebroventricular administration of ILA's, a preparation enriched in insulin-like growth factors, caused a marked decrease in growth hormone secretory episodes and in body weight associated with reduced food intake over 24 hours. Central injection of insulin and bovine serum albumin had no such effects. These findings suggest that insulin-like growth factors play a role in growth hormone negative feedback and body weight regulation at the level of the central nervous system.