Signaling of Cell Fate Decisions by CLAVATA3 in Arabidopsis Shoot Meristems

作者：Jennifer C. Fletcher, Ulrike Brand, Mark Running, Rüdiger Simon, Elliot M. Meyerowitz · 发表于：Science · 年份：1999 · DOI：10.1126/science.283.5409.1911 · 被引用次数：1388 · 研究领域：Plant Reproductive Biology、Plant Molecular Biology Research、Plant Stress Responses and Tolerance

In higher plants, organogenesis occurs continuously from self-renewing apical meristems. Arabidopsis thaliana plants with loss-of-function mutations in the CLAVATA (CLV1, 2, and 3) genes have enlarged meristems and generate extra floral organs. Genetic analysis indicates that CLV1, which encodes a receptor kinase, acts with CLV3 to control the balance between meristem cell proliferation and differentiation. CLV3 encodes a small, predicted extracellular protein. CLV3 acts nonautonomously in meristems and is expressed at the meristem surface overlying the CLV1 domain. These proteins may act as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions.