Molecular pathways in cancer-related inflammation

作者：Annalisa Del Prete, Paola Allavena, Giuseppe Santoro, Ruggiero Fumarulo, Massimiliano Marco Corsi Romanelli, Alberto Mantovani · 发表于：Biochemia Medica · 年份：2011 · DOI：10.11613/bm.2011.036 · 被引用次数：181 · 研究领域：Cancer-related molecular mechanisms research、Inflammatory Biomarkers in Disease Prognosis、Cancer Immunotherapy and Biomarkers

Ac cu mu la ti ng evi den ce shows that chro nic in fl am ma tion is as so cia ted to in crea sed ri sk of can cer.An in fl am ma to ry com po ne nt is pre se nt al so in the mic roen vi ron me nt of tu mou rs epi de mio lo gi cal ly un re la ted to in fl am ma tion.Exten si ve in ves ti ga tio ns over the pa st de ca de ha ve un co ve red ma ny of the im por ta nt mec ha nis tic pat hways un der lyi ng can ce r-re la ted in fl am ma tion.Pat hways lin ki ng in fl am ma tion and can cer ha ve been iden ti fi ed: an in trin sic one (dri ven by ge ne tic even ts that cau se neop la sia) and an extrin sic one (dri ven by in fl am ma to ry con di tio ns whi ch pre dis po se to can cer).Smoul de ri ng in fl am ma tion is a com po ne nt of the tu mour mic roen vi ron me nt and is a re cog ni zed hal lma rk of can cer.Key or ches tra to rs at the in tersec tion of the in trin sic and extrin sic pat hways in clu de tran scrip tion fac to rs (e.g.Nuc lear Fac tor kap pa-B, NFκB) that mo du la te the in fl am ma to ry res pon se throu gh so lub le me dia to rs (cyto ki nes, che mo ki nes) and cel lu lar com po nen ts (e.g.tu mo r-as so cia ted mac rop ha ges), pro mo ti ng tu mo ri gene sis.NFκB aids in the pro li fe ra tion and sur vi val of ma lig na nt cel ls, pro mo tes an gio ge ne sis and me tas ta sis, sub ver ts adap ti ve im mu ni ty, and al te rs res pon ses to hor mo nes and che mot he ra peu tic agen ts.Emer gi ng evi den ce al so sug ges ts that per sis te nt in fl am ma t...