Immunology studies in non‐human primate models of tuberculosis

作者：JoAnne L. Flynn, Hannah P. Gideon, Joshua T. Mattila, Philana Ling Lin · 发表于：Immunological Reviews · 年份：2015 · DOI：10.1111/imr.12258 · 被引用次数：173 · 研究领域：Tuberculosis Research and Epidemiology、Infectious Diseases and Tuberculosis、Mycobacterium research and diagnosis

Non-human primates, primarily macaques, have been used to study tuberculosis for decades. However, in the last 15 years, this model has been refined substantially to allow careful investigations of the immune response and host-pathogen interactions in Mycobacterium tuberculosis infection. Low-dose challenge with fully virulent strains in cynomolgus macaques result in the full clinical spectrum seen in humans, including latent and active infection. Reagents from humans are usually cross-reactive with macaques, further facilitating the use of this model system to study tuberculosis. Finally, macaques develop the spectrum of granuloma types seen in humans, providing a unique opportunity to investigate bacterial and host factors at the local (lung and lymph node) level. Here, we review the past decade of immunology and pathology studies in macaque models of tuberculosis.