Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach

作者：Dan‐Xia Xu, M. Vachon, A. Densmore, R. Ma, A. Delâge, Siegfried Janz, J. Lapointe, Y. Li, Gregory P. Lopinski, D. Zhang, Q. Y. Liu, Pavel Cheben, Jens H. Schmid · 发表于：Optics Letters · 年份：2010 · DOI：10.1364/ol.35.002771 · 被引用次数：106 · 研究领域：Photonic and Optical Devices、Advanced Biosensing Techniques and Applications、Mechanical and Optical Resonators

We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated, with a resolution of 0.3 pg/mm(2) (40 ag of total mass) for protein concentrations over 4 orders of magnitude down to 20 pM. Reactions are measured over time periods as long as 3 h with high stability.