Utility of Lesion Diameter in the Clinical Diagnosis of Cutaneous Melanoma

作者：Naheed R. Abbasi, Molly Yancovitz, Dina Gutkowicz–Krusin, Katherine S. Panageas, Martín C. Mihm, Paul B. Googe, Roy King, Víctor G. Prieto, Iman Osman, Robert J. Friedman, Darrell S. Rigel, Alfred W. Kopf, David Polsky · 发表于：Archives of Dermatology · 年份：2008 · DOI：10.1001/archderm.144.4.469 · 被引用次数：61 · 研究领域：Cutaneous Melanoma Detection and Management、Nonmelanoma Skin Cancer Studies、Melanoma and MAPK Pathways

OBJECTIVE: To determine the utility of the current diameter criterion of larger than 6 mm of the ABCDE acronym for the early diagnosis of cutaneous melanoma. DESIGN: Cohort study. SETTING: Dermatology hospital-based clinics and community practice offices. Patients A total of 1323 patients undergoing skin biopsies of 1657 pigmented lesions suggestive of melanoma. MAIN OUTCOME MEASURE: The maximum lesion dimension (diameter) of each skin lesion was calculated before biopsy using a novel computerized skin imaging system. RESULTS: Of 1657 biopsied lesions, 853 (51.5%) were 6 mm or smaller in diameter. Invasive melanomas were diagnosed in 13 of 853 lesions (1.5%) that were 6 mm or smaller in diameter and in 41 of 804 lesions (5.1%) that were larger than 6 mm in diameter. In situ melanomas were diagnosed in 22 of 853 lesions (2.6%) that were 6 mm or smaller in diameter and in 62 of 804 lesions (7.7%) that were larger than 6 mm in diameter. Conclusion The diameter guideline of larger than 6 mm provides a useful parameter for physicians and should continue to be used in combination with the A, B, C, and E criteria previously established in the selection of atypical lesions for skin biopsy.