cul-1 Is Required for Cell Cycle Exit in C. elegans and Identifies a Novel Gene Family

作者：Edward T. Kipreos, Lois E Lander, John P. Wing, Wei Wu He, Edward M. Hedgecock · 发表于：Cell · 年份：1996 · DOI：10.1016/s0092-8674(00)81267-2 · 被引用次数：451 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Mitochondrial Function and Pathology、Photosynthetic Processes and Mechanisms

The gene cul-1 (formerly lin-19) is a negative regulator of the cell cycle in C. elegans. Null mutations cause hyperplasia of all tissues. cul-1 is required for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway. Moreover, the mutant phenotype suggests that G1-to-S phase progression is accelerated, overriding mechanisms for mitotic arrest and producing abnormally small cells. Significantly, diverse aspects of cell fate and differentiation are unaffected in cul-1 mutants. cul-1 represents a conserved family of genes, designated cullins, with at least five members in nematodes, six in humans, and three in budding yeast.