Nanoencapsulation of Stem Cells within Polyelectrolyte Multilayer Shells

作者：Nalinkanth G. Veerabadran, Poorna L. Goli, Skylar Stewart‐Clark, Yuri Lvov, David K. Mills · 发表于：Macromolecular Bioscience · 年份：2007 · DOI：10.1002/mabi.200700061 · 被引用次数：176 · 研究领域：Polymer Surface Interaction Studies、Hydrogels: synthesis, properties, applications、Electrospun Nanofibers in Biomedical Applications

Mouse mesenchymal stem cells have been individually encased by polyelectrolyte layers of poly (L-lysine) and hyaluronic acid using the electrostatic layer-by-layer assembly technique, resulting in a shell consisting of nanolayers of thickness around 6-9 nm. Maintenance of cell morphology and viability were demonstrated for up to one week. Further adjustments to shell permeability and flexibility will facilitate the use of these encapsulated cells in tissue engineering and targeted-delivery applications.