Antimicrobial, Cytotoxic, and Antiviral Activities of Salvia fructicosa Essential Oil

作者：Afroditi Sivropoulou, Constantina Nikolaou, Eleni Papanikolaou, Stella Kokkini, Θωμάς Λαναράς, Minas Arsenakis · 发表于：Journal of Agricultural and Food Chemistry · 年份：1997 · DOI：10.1021/jf970031m · 被引用次数：210 · 研究领域：Essential Oils and Antimicrobial Activity、Traditional Chinese Medicine Analysis、Phytochemistry and Biological Activities

Salvia fructicosa essential oil analyzed by gas chromatography/mass spectrometry showed high contents of 1,8-cineole, α- and β-thujone, and camphor, representing 47.48%, 11.93%, and 9.04% of the total oil, respectively. The essential oil and its isolated components thujone and 1,8-cineole exhibited antimicrobial activity against eight bacterial strains, while camphor was almost inactive against all of the bacteria tested. The essential oil was bactericidal at 1/4000 dilution, and dilutions up to 1/10000 caused considerable decrease in bacterial growth rates. The essential oil of S. fructicosa and the three main components exhibited cytotoxic activity against African Green Monkey kidney (Vero) cells and high levels of virucidal activity against herpes simplex virus 1, a ubiquitous human virus. Keywords: Salvia fructicosa; essential oil; antimicrobial activity; cytotoxicity; antiviral activity (herpes simplex virus); camphor; 1,8-cineole; thujone