Intestinal Barrier Dysfunction

作者：Jun Gu, Jia Hu, Hong Qian, Yingkang Shi, Eryong Zhang, Yingqiang Guo, Zhenghua Xiao, Zhi Fang, Minghua Zhong, Hongwei Zhang, Wei Meng · 发表于：Journal of Cardiovascular Pharmacology and Therapeutics · 年份：2015 · DOI：10.1177/1074248415581176 · 被引用次数：31 · 研究领域：Aortic Disease and Treatment Approaches、Microbial metabolism and enzyme function、Aortic aneurysm repair treatments

BACKGROUND: Intestinal barrier dysfunction would lead to a rigorous inflammatory reaction due to the translocation of intestinal lumen-derived bacteria and endotoxins. The aim of the present study was to investigate whether intestinal barrier dysfunction occurs in patients with acute Stanford type A aortic dissection (ATAAD) and to determine its potential relationship with the plasma levels of several inflammatory biomarkers in the progression of ATAAD. DESIGN AND METHODS: Serum samples from a total of 46 patients with ATAAD and 36 healthy volunteers were prospectively collected and analyzed. The serum levels of diamine oxidase (DAO), lactate dehydrogenase (LDH), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and C-reactive protein (CRP) were measured using colorimetric assay, enzyme-linked immunosorbent assay, and immunoturbidimetric assay. RESULTS: Serum levels of DAO, LDH, IL-6, TNF-α, and CRP in patients with ATAAD were significantly higher than those in healthy participants. A significantly positive correlation between DAO activity and IL-6 (r = .56, P < .001), TNF-α (r = .63, P < .001), and CRP (r = .53, P < .001) was observed. Moreover, the activity of DAO correlated negatively with the Pao 2/fraction of inspired oxygen (Fio 2) ratio (r = -.39, P = .007). CONCLUSIONS: Intestinal barrier dysfunction, reflected by an increased level of serum DAO, may play an important role in the development of systemic inflammatory responses in patients with ATAAD. Therefore, st...