Post-mortem Study of Chronic Schizophrenic Brains

作者：Bente Pakkenberg · 发表于：The British Journal of Psychiatry · 年份：1987 · DOI：10.1192/bjp.151.6.744 · 被引用次数：205 · 研究领域：Schizophrenia research and treatment、Advanced Neuroimaging Techniques and Applications、Functional Brain Connectivity Studies

Volume measurements were carried out on 29 brains from institutionalised, chronic schizophrenic patients and 30 age and sex-matched controls using a stereological method. The volumes of the total fixated brain, the hemispheres, the cortex, and the central grey matter of the schizophrenic brains were significantly reduced while the volumes of the ventricles were significantly enlarged compared with the control group. The patients had been diagnosed by a psychiatrist on the basis of their case records as having either a Type I or Type II syndrome according to the symptoms they presented in the first years of their disease. The Type II patients were found to have significantly enlarged ventricles compared with the Type I patients.