Capture and Stimulated Release of Circulating Tumor Cells on Polymer‐Grafted Silicon Nanostructures

作者：Shuang Hou, Haichao Zhao, Libo Zhao, Qinglin Shen, Kevin Wei, Daniel Y. Suh, Aiko Nakao, Mitch A. Garcia, Min Song, Tom Lee, Bin Xiong, Shyh‐Chyang Luo, Hsian‐Rong Tseng, Hsiao‐hua Yu · 发表于：Advanced Materials · 年份：2012 · DOI：10.1002/adma.201203185 · 被引用次数：259 · 研究领域：Advanced biosensing and bioanalysis techniques、Molecular Communication and Nanonetworks、Graphene and Nanomaterials Applications

A platform for capture and release of circulating tumor cells is demonstrated by utilizing polymer grafted silicon nanowires. In this platform, integration of ligand-receptor recognition, nanostructure amplification, and thermal responsive polymers enables a highly efficient and selective capture of cancer cells. Subsequently, these captured cells are released upon a physical stimulation with outstanding cell viability.