Prognostic Significance of Preoperative [18-F] Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) Imaging in Patients With Resectable Soft Tissue Sarcomas

作者：Matthias Schwarzbach, Ulf Hinz, Antonia Dimitrakopoulou‐Strauss, Frank Willeke, Servando Cardona, Gunhild Mechtersheimer, Thomas Lehnert, Ludwig G. Strauss, Christian H. Herfarth, Markus Wolfgang Büchler · 发表于：Annals of Surgery · 年份：2005 · DOI：10.1097/01.sla.0000152663.61348.6f · 被引用次数：112 · 研究领域：Sarcoma Diagnosis and Treatment、Lung Cancer Diagnosis and Treatment、Soft tissue tumor case studies

In Brief Objective: The objective of this study was to evaluate the prognostic significance of preoperative positron emission tomography (PET) using 2-fluoro-2-deoxy-D-glucose (FDG) by calculating the mean standardized uptake values (SUV) in patients with resectable soft tissue sarcomas (STS). Summary and Background Data: FDG-PET might be used as an adjunctive tool (in addition to biopsy and radiologic tomography) in the preoperative prognostic assessment of resectable STS. Methods: A total of 74 adult patients with STS underwent preoperative FDG-PET imaging with calculation of the SUV. Clinicopathologic data and the SUV were analyzed for an association with the clinical outcome. The first and the third quartiles of the SUV distribution function were used as cutoff values (1.59 and 3.6). Survival was estimated by the Kaplan-Meier method. Univariate and multivariate analyses were performed using log-rank test and the Cox proportional hazards regression model. Results: In 55 cases, STS were completely resected (follow up 40 months): 5-year recurrence-free survival rates in patients with SUV <1.59, 1.59 to <3.6, and ≥3.6 were 66%, 24%, and 11%, respectively (P = 0.0034). SUV was a predictor for overall survival (5-year rates: 84% [SUV <1.59], 45% [SUV 1.59 to <3.6], and 38% [SUV ≥3.6]; P = 0.057) and local tumor control (5-year rates: 93% [SUV <1.59], 43% [SUV 1.59 to <3.6], and 15% [SUV ≥3.6]; P = 0.0017). By multivariate analysis, SUV was found to be predictive for recurrence-...