Role of advanced glycation end products in cellular signaling

作者：Christiane Ott, Kathleen E. Jacobs, Elisa Haucke, Anne Navarrete Santos, Tilman Grune, Andreas Simm · 发表于：Redox Biology · 年份：2014 · DOI：10.1016/j.redox.2013.12.016 · 被引用次数：1144 · 研究领域：Advanced Glycation End Products research、Natural Antidiabetic Agents Studies、Fatty Acid Research and Health

Improvements in health care and lifestyle have led to an elevated lifespan and increased focus on age-associated diseases, such as neurodegeneration, cardiovascular disease, frailty and arteriosclerosis. In all these chronic diseases protein, lipid or nucleic acid modifications are involved, including cross-linked and non-degradable aggregates, such as advanced glycation end products (AGEs). Formation of endogenous or uptake of dietary AGEs can lead to further protein modifications and activation of several inflammatory signaling pathways. This review will give an overview of the most prominent AGE-mediated signaling cascades, AGE receptor interactions, prevention of AGE formation and the impact of AGEs during pathophysiological processes.