Selective Inhibition of Fibronectin-Mediated Cell Adhesion by Monoclonal Antibodies to a Cell-Surface Glycoprotein

作者：Patricia J. Brown, Rudy L. Juliano · 发表于：Science · 年份：1985 · DOI：10.1126/science.4012302 · 被引用次数：216 · 研究领域：Cell Adhesion Molecules Research、Cellular Mechanics and Interactions、Monoclonal and Polyclonal Antibodies Research

Fibroblasts possess several distinct mechanisms that control cellular adhesion to extracellular matrix macromolecules. Monoclonal antibodies to a 140-kilodalton (kD) cell surface glycoprotein inhibited the adhesion of fibroblastic Chinese hamster ovary cells to fibronectin-coated substrata but did not inhibit adhesion to substrata coated with vitronectin, laminin, serum, or other adhesive macromolecules. Thus the 140-kD glycoprotein appears to be involved in the fibronectin-mediated adhesion mechanism but not in other adhesion processes.