Synergistic activation of human t cells by interleukin 1 and interleukin 6

作者：Frédéric Houssiau, Pierre G. Coulie, Daniel Olive, Jacques Van Snick · 发表于：European Journal of Immunology · 年份：1988 · DOI：10.1002/eji.1830180427 · 被引用次数：152 · 研究领域：Immune Cell Function and Interaction

Purified human interleukin 6 (IL 6) was found to stimulate the proliferation of human tonsillar and peripheral rosetting T cells subliminally activated with phytohemagglutinin (PHA). This response seemed independent of IL 2 but highly dependent on the presence of accessory cells. Indeed, when accessory cell-depleted tonsillar T cells were activated with PHA and exposed to IL 6, only minimal proliferations were observed. A similar result was obtained with IL 1. However, a combination of these two cytokines induced strong proliferations, indicating that IL 1 and IL 6 plays a synergistic role in the interactions between accessory cells and T lymphocytes.