Comparison of cell growth in different parts of breast cancers

作者：Didier Verhoeven, N. Bourgeois, M.P. Derde, L. Kaufman, Norbert Buyssens · 发表于：Histopathology · 年份：1990 · DOI：10.1111/j.1365-2559.1990.tb00789.x · 被引用次数：38 · 研究领域：Cancer Genomics and Diagnostics、Cancer Cells and Metastasis、AI in cancer detection

This study was performed to answer the question: which parts of breast cancers are active in terms of proliferation as measured by the Ki-67 antibody and in terms of cell division as measured by the mitotic index. Forty-six breast samples were studied, including 34 breast cancers and 12 benign conditions. The intraductal component of infiltrating breast cancers showed a significantly lower proliferation index than the infiltrating component. The cells at the periphery of infiltrating tumour strands showed a higher proliferation activity than the cells in the core. These findings suggest that infiltration advances through preferential active growth of the cells at the invasion front.