The Use of Catalytic Amounts of CuCl and Other Improvements in the Benzyne Route to Biphenyl-Based Phosphine Ligands

作者：Steven S. Kaye, Joseph M. Fox, Frederick A. Hicks, Stephen L. Buchwald · 发表于：Advanced Synthesis & Catalysis · 年份：2001 · DOI：10.1002/1615-4169(20011231)343:8<789::aid-adsc789>3.0.co;2-a · 被引用次数：119 · 研究领域：Cyclization and Aryne Chemistry、Catalytic Alkyne Reactions、Synthetic Organic Chemistry Methods

Biphenyl-based phosphine ligands can be prepared on a significantly larger scale than previously possible as a result of the following discoveries and improvements to the original experimental procedure: the finding that CuCl catalyzes the coupling of hindered dialkylchlorophosphines with Grignard reagents; the development of conditions that permit ClPCy2 to be prepared and utilized in situ; the development of a more reliable large-scale preparation of 2-dimethylaminophenylmagnesium halide.