Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

作者：Akihiko Matsumine, Akiko Ogai, Takao Senda, Nobuaki Okumura, Kiyotoshi Satoh, Gyeong‐Hun Baeg, Takeo KAWAHARA, Shigeru Kobayashi, Masato Okada, Kumao Toyoshima, Tetsu Akiyama · 发表于：Science · 年份：1996 · DOI：10.1126/science.272.5264.1020 · 被引用次数：425 · 研究领域：Genetic factors in colorectal cancer、Cancer-related Molecular Pathways、Wnt/β-catenin signaling in development and cancer

The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its product binds to the adherens junction protein beta-catenin. Overexpression of APC blocks cell cycle progression. The APC-beta-catenin complex was shown to bind to DLG, the human homolog of the Drosophila discs large tumor suppressor protein. This interaction required the carboxyl-terminal region of APC and the DLG homology repeat region of DLG. APC colocalized with DLG at the lateral cytoplasm in rat colon epithelial cells and at the synapse in cultured hippocampal neurons. These results suggest that the APC-DLG complex may participate in regulation of both cell cycle progression and neuronal function.