Five New Triterpene Glycosides from Lysimachia foenum-graecum and Evaluation of their Effect on the Arachidonic Acid Metabolizing Enzyme

作者：Yun‐Heng Shen, Zhiying Weng, Qin‐Shi Zhao, Yue-Qin Zeng, José-Luis Rı́os, Wei‐Lie Xiao, Gang Xu, Han‐Dong Sun · 发表于：Planta Medica · 年份：2005 · DOI：10.1055/s-2005-871289 · 被引用次数：23 · 研究领域：Natural product bioactivities and synthesis、Phytochemistry and Biological Activities、Plant biochemistry and biosynthesis

Five new oleanane-type triterpene saponins, named foenumosides A ( 1), B ( 2), C ( 3), D ( 4) and E ( 5), were isolated from the aerial parts of Lysimachia foenum-graecum Hance. Their structures were identified on the basis of 1D and 2D NMR techniques, including H-H COSY, HMQC, HMBC, HMQC-TOCSY, ROESY experiments as well as chemical methods. We have evaluated the cytotoxity of 1 - 5 against rat and human polymorphonuclear leukocytes and the effect of 5 on the arachidonic acid metabolizing enzyme. All compounds showed a high degree of toxicity except for compound 5, while 5 notably reduced the production of leukotriene B (4) (LTB (4)) from rat peritoneal leukocytes with an IC (50) value of 74 microM without inhibiting human elastase. Compound 5 also reduced the production of 12-HHTrE and 12-HETE by 14 % and 50 % as a measurement for cyclooxygenase-1 and 12-lipoxygenase inhibition at 100 microM.