Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

作者：Sonia Sharma, Benjamin R. tenOever, Nathalie Grandvaux, Guoping Zhou, Rongtuan Lin, John Hiscott · 发表于：Science · 年份：2003 · DOI：10.1126/science.1081315 · 被引用次数：1681 · 研究领域：interferon and immune responses、Immune Response and Inflammation、NF-κB Signaling Pathways

Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK)-related kinases IKKepsilon and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.