6-Hydroxydopamine: Evidence for Superoxide Radical as an Oxidative Intermediate

作者：Richard E. Heikkila, Gerald Leonard Cohen · 发表于：Science · 年份：1973 · DOI：10.1126/science.181.4098.456 · 被引用次数：258 · 研究领域：Insect and Pesticide Research、Free Radicals and Antioxidants、Cholinesterase and Neurodegenerative Diseases

Superoxide dismutase inhibited the autoxidation of 6-hydroxydopamine as measured by the rate of formation of a quinone and the rate of oxygen consumption. These observations demonstrate the formation of the superoxide radical during the autoxidation process. This finding may be relevant to the mechanism of adrenergic nerve terminal degeneration caused by 6-hydroxydopamine.