The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.

作者：Hua Lu, Osvaldo A. Flores, Roberto Simon Weinmann, Danny Reinberg · 发表于：Proceedings of the National Academy of Sciences · 年份：1991 · DOI：10.1073/pnas.88.22.10004 · 被引用次数：325 · 研究领域：RNA modifications and cancer、RNA Research and Splicing、DNA Repair Mechanisms

The two forms of RNA polymerase II that exist in vivo, phosphorylated (IIO) and nonphosphorylated (IIA), were purified to apparent homogeneity from HeLa cells. The nonphosphorylated form preferentially binds to the preinitiation complex. RNA polymerase II in the complex was converted by a cellular protein kinase to the phosphorylated form.