Silver-Mediated Fluorination of Functionalized Aryl Stannanes

作者：Takeru Furuya, Alexandra E. Strom, Tobias Ritter · 发表于：Journal of the American Chemical Society · 年份：2009 · DOI：10.1021/ja8086664 · 被引用次数：303 · 研究领域：Fluorine in Organic Chemistry、Inorganic Fluorides and Related Compounds、Catalytic C–H Functionalization Methods

We report a regiospecific silver-mediated fluorination of aryl stannanes. The presented reaction can afford complex fluoroarenes from readily available phenols in three steps. The operational simplicity and the broad substrate scope of the fluorination should render this reaction a useful tool for the synthesis of milligram to gram quantities of functionalized aryl fluorides. Silver-mediated oxidative transformations of aryl nucleophiles that proceed via bimetallic redox processes are a new avenue to develop carbon-heteroatom bond formations.