The role of CD4+ T cell responses in antitumor immunity

作者：Drew M. Pardoll, Suzanne Louise Topalian · 发表于：Current Opinion in Immunology · 年份：1998 · DOI：10.1016/s0952-7915(98)80228-8 · 被引用次数：681 · 研究领域：Immunotherapy and Immune Responses、T-cell and B-cell Immunology、Immune Cell Function and Interaction

While most of the focus in cancer immunology is on CD8+ cytotoxic T lymphocyte responses, recent evidence indicates that CD4+ T cells are an equally critical component of the antitumor immune response. Successful immunity to cancer will therefore require activation of tumor-specific CD4+ T cells. Tumor antigens recognized by CD4+ T cells that are restricted by MHC class II are beginning to be defined in both murine and human tumors. These will provide the basis for new generations of antigen-specific tumor vaccines.