The evaluation of low dose pre-operative X-ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

作者：Second Report of an MRC Working Party, W. Duncan, A. N. Smith, Laurence S. Freedman, M R Alderson, S.J. Arnott, N. M. Bleehen, William H. Bond, D. Crowther, Thomas J. Deeley, H L Duthie, Peter W. Dykes, L. PETER FIELDING, G. E. Flatman, John C. Goligher, Peter R. Hawley, L E Hughes, C. A. Joslin, Osama M. Koriech, B C Morson, G.D. Oates, Michael Peckham, M. R. Sandland, P F Schofield, William Slack, Geoffrey Slaney, Jessica A. Smith, John S. Scott, J. M. A. Whitehouse, P. F. M. Wrigley, A York-Mason · 发表于：British journal of surgery · 年份：1984 · DOI：10.1002/bjs.1800710107 · 被引用次数：223 · 研究领域：Colorectal Cancer Surgical Treatments、Colorectal and Anal Carcinomas、Radiomics and Machine Learning in Medical Imaging

824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence-free and metastasis-free rates are similar in all groups. There is also no evidence that the pre-operative radiotherapy benefited patients in subgroups by Dukes' stage. The complication rates were also similar in the three treatment groups.