A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin

作者：Longyan Liao, Jenny Liu, Erik C. Dreaden, Stephen W. Morton, Kevin E. Shopsowitz, Paula T. Hammond, Jeremiah A. Johnson · 发表于：Journal of the American Chemical Society · 年份：2014 · DOI：10.1021/ja502011g · 被引用次数：365 · 研究领域：Nanoparticle-Based Drug Delivery、Nanoplatforms for cancer theranostics、Graphene and Nanomaterials Applications

The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry precise molar ratios of doxorubicin, camptothecin, and cisplatin. To our knowledge, this work provides the first example of orthogonally triggered release of three drugs from single NPs. The highly convergent synthetic approach opens the door to new NP-based combination therapies for cancer.