Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients

作者：Ozren Polašek, Grgo Gunjača, Ivana Kolčić, Lina Zgaga, Snježana Džijan, Robert Smolić, Martina Smolić, Jasminka Milas-Ahić, Vatroslav Šerić, Josip Galić, Sandra Tucak-Zorić, Antun Tucak, Igor Rudan, Gordan Lauc · 发表于：Croatian Medical Journal · 年份：2010 · DOI：10.3325/cmj.2010.51.48 · 被引用次数：21 · 研究领域：Gout, Hyperuricemia, Uric Acid、Parathyroid Disorders and Treatments、Kidney Stones and Urolithiasis Treatments

AIM: To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9. METHODS: A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267). RESULTS: There was a weak but significant association of all 4 SNPs and nephrolithiasis (P=0.029 for rs733175; P=0.006 for rs6449213; P=0.020 for rs1014290, and P=0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance. CONCLUSION: Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.