On the Interactions of Lipids and Proteins in the Red Blood Cell Membrane

作者：Michael Gläser, Henry Simpkins, Sherwin J. Singer, Michael P. Sheetz, Sunney I. Chan · 发表于：Proceedings of the National Academy of Sciences · 年份：1970 · DOI：10.1073/pnas.65.3.721 · 被引用次数：133 · 研究领域：Lipid Membrane Structure and Behavior、Erythrocyte Function and Pathophysiology、Protein Structure and Dynamics

The effects of temperature and of the action of a purified phospholipase C enzyme preparation on human red blood cell membranes has been investigated by chemical analyses, circular dichroism, and proton magnetic resonance measurements. The results indicate that a substantial fraction of the phospholipids and the proteins of the membranes can change structure independently of one another, suggesting a mosaic pattern for the organization of the lipids and proteins in membranes.