Effects of danazol and lynestrenol on serum lipoproteins in endometriosis

作者：Marjatta Mälkönen, Vesa Manninen, E Hirvonen · 发表于：Clinical Pharmacology & Therapeutics · 年份：1980 · DOI：10.1038/clpt.1980.209 · 被引用次数：29 · 研究领域：Endometriosis Research and Treatment、Estrogen and related hormone effects

The treatment of endometriosis with danazol or lynestrenol decreased cholesterol content of plasma high-density lipoproteins by 50% and 32%. There were simultaneous increases in low-density lipoprotein cholesterol content of 51% and 19%. We suggest that changes induced by lynestrenol are due to progestational activity, while in the case of danazol both antigonadotropic and androgenic activities are involved. Clinical Pharmacology and Therapeutics (1980) 28, 602–604; doi:10.1038/clpt.1980.209