Protection of Mice by an Apathogenic Strain of HSV-1 Against Lethal Infection by a Pathogenic Strain of HSV-1

作者：Christoph Schröder, Helmut Engler, Holger Kirchner · 发表于：Journal of General Virology · 年份：1981 · DOI：10.1099/0022-1317-52-1-159 · 被引用次数：39 · 研究领域：Herpesvirus Infections and Treatments、Toxin Mechanisms and Immunotoxins、Viral Infectious Diseases and Gene Expression in Insects

DBA/2 and C57BL/6 mice were infected intraperitoneally with two different strains of herpes simplex virus type 1, HSV-1 ANG and HSV-1 WAL. Unlike HSV-1 WAL, HSV-1 ANG was apathogenic by this mode of infection. Furthermore, infection with HSV-1 ANG protected mice of both inbred strains against infections with lethal doses of pathogenic HSV-1 WAL. This protection was observed when the apathogenic virus was given with the pathogenic virus or 4 to 24 h before it.