Clot-Selective Coronary Thrombolysis with Tissue-Type Plasminogen Activator

作者：Steven R. Bergmann, Keith A.A. Fox, Michel M. Ter‐Pogossian, Burton E. Sobel, Désiré Collen · 发表于：Science · 年份：1983 · DOI：10.1126/science.6602378 · 被引用次数：238 · 研究领域：Coronary Interventions and Diagnostics、Acute Myocardial Infarction Research、Cell Adhesion Molecules Research

Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.