Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III

作者：N L Letvin, Muthiah D. Daniel, Prabhat K. Sehgal, R. C. Desrosiers, R. D. Hunt, Linda M. Waldron, John J. Mackey, Diane K. Schmidt, Laura V. Chalifoux, N. W. King · 发表于：Science · 年份：1985 · DOI：10.1126/science.2412295 · 被引用次数：619 · 研究领域：T-cell and Retrovirus Studies、Animal Disease Management and Epidemiology、Herpesvirus Infections and Treatments

The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4+ peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.