Serotonin as a stimulator of hippocampal cell differentiation in tissue culture

作者：H. A. Gromova, A R Chubakov, Chumasov Ei, Henrich V Konovalov · 发表于：International Journal of Developmental Neuroscience · 年份：1983 · DOI：10.1016/0736-5748(83)90015-1 · 被引用次数：52 · 研究领域：Chemical Reactions and Isotopes、Neuroscience and Neuropharmacology Research、Nicotinic Acetylcholine Receptors Study

The effects of serotonin (5-HT) on morphofunctional development of hippocampal cultures derived from newborn rats were studied. It was established that systematic addition of 5-HT to nutrient medium during cultivation stimulates neuropil development, axon myelination and synaptogenesis. Electrophysiological studies of hippocampal cells in 5-HT treated cultures showed earlier exhibition of spontaneous activity and an increased number of spontaneously firing neurons and prevalence of periodic (bursting) type of discharges. These results indicate that 5-HT stimulates the differentiation of hippocampal cells in tissue culture.