Gastrointestinal-Motility Dysfunction in Amyloidosis

作者：William M. Battle, Marc R. Rubin, Sidney Cohen, William J. Snape · 发表于：New England Journal of Medicine · 年份：1979 · DOI：10.1056/nejm197907053010105 · 被引用次数：111 · 研究领域：Amyloidosis: Diagnosis, Treatment, Outcomes、Parathyroid Disorders and Treatments、Pancreatitis Pathology and Treatment

SYSTEMIC amyloidosis frequently involves the gastrointestinal tract and may result in obstruction, malabsorption, ulceration, hemorrhage or perforation as well as impaired motility.1 2 3 It is unclear whether the impaired gastrointestinal motility is secondary to the effects of amyloid on the smooth muscle or on the autonomic nervous system. We report on a patient with primary amyloidosis, in whom esophageal manometric and colonic myoelectric studies revealed a widespread disorder of gastrointestinal motility. The evidence suggests that neural dysfunction contributes to the abnormal motility associated with amyloidosis.Case ReportA 68-year-old woman was admitted to the Hospital of the University of Pennsylvania with . . .