Sequence-Encoded Self-Assembly of Multiple-Nanocomponent Arrays by 2D DNA Scaffolding

作者：Yariv Pinto, John D. Le, Nadrian C. Seeman, Karin Musier‐Forsyth, T. Andrew Taton, R.A. Kiehl · 发表于：Nano Letters · 年份：2005 · DOI：10.1021/nl0515495 · 被引用次数：234 · 研究领域：Advanced biosensing and bioanalysis techniques、DNA and Biological Computing、Modular Robots and Swarm Intelligence

Regular 2D arrays of multiple types of nanocomponents were constructed by self-assembly to DNA scaffolding with alternating rows of sequence-encoded hybridization sites. Different-sized Au particles coated with DNA complementary to one of the sites were bound to the scaffolding, producing alternating rows of the two nanocomponents with a 32-nm inter-row spacing. These results demonstrate the potential for using DNA to self-assemble complex arrays of components with nanometer-scale precision.