Neurochemical Effects of Theta Burst Stimulation as Assessed by Magnetic Resonance Spectroscopy

作者：Charlotte J. Stagg, Marzena Wylezinska, Paul M. Matthews, Heidi Johansen‐Berg, Peter Jezzard, John C. Rothwell, Sven Bestmann · 发表于：Journal of Neurophysiology · 年份：2009 · DOI：10.1152/jn.91060.2008 · 被引用次数：299 · 研究领域：Transcranial Magnetic Stimulation Studies、Muscle activation and electromyography studies、Neuroscience and Neural Engineering

Continuous theta burst stimulation (cTBS) is a novel transcranial stimulation technique that causes significant inhibition of synaptic transmission for ≤1 h when applied over the primary motor cortex (M1) in humans. Here we use magnetic resonance spectroscopy to define mechanisms mediating this inhibition by noninvasively measuring local changes in the cortical concentrations of γ-aminobutyric acid (GABA) and glutamate/glutamine (Glx). cTBS to the left M1 led to an increase in GABA compared with stimulation at a control site without significant change in Glx. This direct evidence for increased GABAergic interneuronal activity is framed in terms of a new hypothesis regarding mechanisms underlying cTBS.