Enhanced gene transfection capability of polyethylenimine by incorporating boronic acid groups

作者：Peng Qi, Fujie Chen, Zhenlin Zhong, Ren‐Xi Zhuo · 发表于：Chemical Communications · 年份：2010 · DOI：10.1039/c0cc00877j · 被引用次数：96 · 研究领域：RNA Interference and Gene Delivery、Advanced biosensing and bioanalysis techniques、Virus-based gene therapy research

Phenylboronic acid-modified PEI was prepared by the reaction of 1800 Da PEI with 4-(bromomethyl)phenylboronic acid. It is much more effective than unmodified PEI for gene delivery. The covalently incorporated boronic acid groups achieve the greatly enhanced gene delivery efficiency partially through improving condensation ability to DNA, and partially through facilitating cell uptake due to interaction with ligands in cells.