Regulation of the Germinal Center Response by MicroRNA-155

作者：To‐Ha Thai, Dinis Pedro Calado, Stefano S Casola, Karl Mark Ansel, Changchun Xiao, Yingzi Xue, Andrew J. Murphy, David A. Frendewey, David M. Valenzuela, Jeffery Lorne Kutok, Marc Schmidt‐Supprian, Nikolaus Rajewsky, George D. Yancopoulos, Anjana Rao, Klaus Rajewsky · 发表于：Science · 年份：2007 · DOI：10.1126/science.1141229 · 被引用次数：1488 · 研究领域：MicroRNA in disease regulation、Cancer-related molecular mechanisms research、Circular RNAs in diseases

MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.