Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

作者：James Robert Bischoff, Paula N. Friedman, D R Marshak, Carol L. Prives, David Beach · 发表于：Proceedings of the National Academy of Sciences · 年份：1990 · DOI：10.1073/pnas.87.12.4766 · 被引用次数：352 · 研究领域：Cancer-related Molecular Pathways、Molecular Biology Techniques and Applications、Cancer Research and Treatments

The human anti-oncoprotein p53 is shown to be a substrate of cdc2. The primary site of phosphorylation is serine-315. Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes. The phosphorylation of p53 is cell cycle-dependent. The abundance of p53 also oscillates during the cell cycle. The protein is largely absent from cells that have just completed division but accumulates in cells during G1 phase. Phosphorylation by cdc2 might regulate the antiproliferative activity of p53.