Secondary Structure Prediction for the Spectrin 106-Amino Acid Segment, and a Proposed Model for Tertiary Structure

作者：Y. Xu, Madhupriya Prabhakaran, Michael E. Johnson, L.W.‐M. Fung · 发表于：Journal of Biomolecular Structure and Dynamics · 年份：1990 · DOI：10.1080/07391102.1990.10507789 · 被引用次数：12 · 研究领域：Erythrocyte Function and Pathophysiology、Protein Structure and Dynamics、Enzyme Structure and Function

A collective secondary structure prediction for the human erythrocyte spectrin 106-residue repeat segment is developed, based on the sequences of nine segments that have been reported in the literature, utilizing a consensus of several secondary structure prediction methods for locating turn regions. The analysis predicts a five-fold structure, with three alpha-helices and two beta-strand regions, and differs from previous models on the lengths of the helices and the existence of beta-strand structure. We also demonstrate that this structural motif can be folded into tertiary structures that satisfy the experimental spectrin data and several general principles of protein organization.