The Metabolism of Phosphoinositide-Derived Messenger Molecules

作者：Philip W. Majerus, Thomas M Connolly, Hans Deckmyn, Theodora Suzanne Ross, Teresa E. Bross, Hidemi Ishii, Vinay S. Bansal, David Brown Wilson · 发表于：Science · 年份：1986 · DOI：10.1126/science.3024320 · 被引用次数：720 · 研究领域：Metabolism and Genetic Disorders、Protein Kinase Regulation and GTPase Signaling、Peroxisome Proliferator-Activated Receptors

The phosphoinositides are minor phospholipids present in all eukaryotic cells. They are storage forms for messenger molecules that transmit signals across the cell membrane and evoke responses to extracellular agonists. The phosphoinositides break down to liberate messenger molecules or precursors of messenger molecules. Many different compounds are formed, although the functions of only a few are understood. Recent studies elaborating the pathways for formation of products from phosphoinositides and the factors controlling their metabolism are summarized here.