Prospective Study of One Million Deaths in India: Rationale, Design, and Validation Results

作者：Prabhat Jha, Vendhan Gajalakshmi, Prakash Chandra Gupta, Rajesh Kumar, Prem Kumar Mony, Neeraj Dhingra, Richard Peto, RGI-CGHR Prospective Study Collaborators · 发表于：PLoS Medicine · 年份：2005 · DOI：10.1371/journal.pmed.0030018 · 被引用次数：326 · 研究领域：Autopsy Techniques and Outcomes、Global Maternal and Child Health、Insurance, Mortality, Demography, Risk Management

BACKGROUND: Over 75% of the annual estimated 9.5 million deaths in India occur in the home, and the large majority of these do not have a certified cause. India and other developing countries urgently need reliable quantification of the causes of death. They also need better epidemiological evidence about the relevance of physical (such as blood pressure and obesity), behavioral (such as smoking, alcohol, HIV-1 risk taking, and immunization history), and biological (such as blood lipids and gene polymorphisms) measurements to the development of disease in individuals or disease rates in populations. We report here on the rationale, design, and implementation of the world's largest prospective study of the causes and correlates of mortality. METHODS AND FINDINGS: We will monitor nearly 14 million people in 2.4 million nationally representative Indian households (6.3 million people in 1.1 million households in the 1998-2003 sample frame and 7.6 million people in 1.3 million households in the 2004-2014 sample frame) for vital status and, if dead, the causes of death through a well-validated verbal autopsy (VA) instrument. About 300,000 deaths from 1998-2003 and some 700,000 deaths from 2004-2014 are expected; of these about 850,000 will be coded by two physicians to provide causes of death by gender, age, socioeconomic status, and geographical region. Pilot studies will evaluate the addition of physical and biological measurements, specifically dried blood spots. Preliminary res...