Walk-Run Training Improves the Anti-Inflammation Properties of High-Density Lipoprotein in Patients With Metabolic Syndrome

作者：Hui Sang, Shutong Yao, Liying Zhang, Xiuhong Li, Nana Yang, Jianxiang Zhao, Li Zhao, Yanhong Si, Ying Zhang, Lv Xiaohong, Yazhuo Xue, Shucun Qin · 发表于：The Journal of Clinical Endocrinology & Metabolism · 年份：2014 · DOI：10.1210/jc.2014-2979 · 被引用次数：49 · 研究领域：Paraoxonase enzyme and polymorphisms、Adipokines, Inflammation, and Metabolic Diseases、Diabetes, Cardiovascular Risks, and Lipoproteins

CONTEXT: Metabolic syndrome (MetS) is a constellation of cardiovascular risk factors, including central obesity, dysglycemia, hypertension, and dyslipidemia. The anti-inflammatory properties of high density lipoprotein (HDL) can be compromised in MetS. Exercise is recognized as an important factor in the prevention and treatment of MetS. OBJECTIVE: This study was designed to investigate whether walk/run training without any specific diet could enhance anti-inflammation capacity of HDL from MetS patients. DESIGN: This was a case control study. SETTING: The study was conducted in a Zhoudian community, Taian. PATIENTS: Thirty nine patients with MetS were recruited and divided into a control group (n = 12) remaining in an untrained state and exercise group (n = 27) performing a 10-week walk/run training program. MAIN OUTCOME MEASURES: The anti-inflammation capacities of HDL3 (HDL subfractions) from MetS patients with or without exercise were investigated by co-incubating with TNF- α-injured endothelial cells in vitro. RESULTS: The training did not influence serum lipoprotein level in MetS patients and cholesterol efflux capacity of circulating HDL. However, walk/run training increased paraoxonase-1 (PON1) activity and decreased the levels of malondialdehyde in either serum or isolated HDL from MetS patients prominently. More importantly, HDL3 isolated from MetS patients with 10 weeks training protected endothelial cells against tumor necrosis factor-a (TNF-a) -induced injury, dec...