Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

作者：Ruth Steward · 发表于：Science · 年份：1987 · DOI：10.1126/science.3118464 · 被引用次数：486 · 研究领域：Developmental Biology and Gene Regulation、Animal Genetics and Reproduction、Neurobiology and Insect Physiology Research

The Drosophila gene, dorsal, is a maternal effect locus that is essential for the establishment of dorsal-ventral polarity in the developing embryo. The dorsal protein was predicted from the complementary DNA sequence; it is almost 50 percent identical, over an extensive region, to the protein encoded by the avian oncogene v-rel, its cellular homolog, c-rel, and a human c-rel fragment. The oncogene v-rel is highly oncogenic in avian lymphoid, spleen, and bone marrow cells.