Tooth analyses of sources and intensity of lead exposure in children.

作者：Brian L. Gulson · 发表于：Environmental Health Perspectives · 年份：1996 · DOI：10.1289/ehp.96104306 · 被引用次数：87 · 研究领域：Heavy Metal Exposure and Toxicity、Mercury impact and mitigation studies、Heavy metals in environment

The sources and intensity of lead exposure in utero and in early childhood were determined using stable lead isotopic ratios and lead concentrations of incisal and cervical sections of deciduous teeth from 30 exposed and nonexposed children from the Broken Hill lead mining community in Australia. Incisal sections, consisting mostly of enamel, generally have low amounts of lead and isotopic compositions consistent with those expected in the mother during pregnancy. Cervical sections, consisting mostly of dentine with secondary dentine removed by resorption and reaming, generally have higher amounts of lead than the enamel and isotopic compositions consistent with the source of postnatal exposure. There are statistically significant differences in lead concentrations between incisal and cervical sections, representing within-tooth variation, for children with low and high lead exposure (p = 0.0007, 2 x 10(-6), respectively) and for those who have ingested leaded paint (p = 0.009). Statistically significant differences between incisal and cervical sections in these three exposure groups are also exhibited by the three sets of lead isotope ratios (e.g., p = 0.001 for 206Pb/204Pb ratio in the low exposure group). There are statistically significant differences between the low and high lead exposure groups for lead concentrations and isotopic ratios in incisal (p = 0.005 for lead concentration and 6 x 10(-6) for 206Pb/204Pb ratio) and cervical sections (p = 5 x 10(-5) for lead conc...