Allogeneic tumor rejection induced by the intravenous injection of Lyt-2+ cytolytic T lymphocyte clones.

作者：Howard D Engers, Andrew L. Glasebrook, George D. Sorenson · 发表于：The Journal of Experimental Medicine · 年份：1982 · DOI：10.1084/jem.156.4.1280 · 被引用次数：84 · 研究领域：Radiopharmaceutical Chemistry and Applications、CAR-T cell therapy research、Cancer Research and Treatments

The in vivo activity of murine Lyt-2+ cytolytic T lymphocyte clones was assessed in a tumor allograft model system. Mice that had been sublethally irradiated 16 h previously were injected intraperitoneally with 131I-IUdR-labeled tumor cells. Simultaneously, various doses of four cytolytic T cell clones were injected intravenously and the mice monitored for tumor cell elimination by whole-body counting tecniques. These four clones had been selected on the basis of their ability to proliferate in response to alloantigens in the absence of added T cell growth factor(s). With two of the four clones tested, rapid elimination of tumor cells within the peritoneal cavity was observed, as early as 48 h after intravenous injection of the cloned T cells.