ANTIMICROBIAL CHEMOTHERAPY IN CYSTIC FIBROSIS PATIENTS

作者：Niels Høiby, B Friis, Klaus Skovbo Jensen, Christian Koch, Niels Erik Møller, Søren Støvring, MARTHA SZAFF · 发表于：Acta Paediatrica · 年份：1982 · DOI：10.1111/j.1651-2227.1982.tb09643.x · 被引用次数：89 · 研究领域：Cystic Fibrosis Research Advances、Pneumonia and Respiratory Infections、Antibiotic Resistance in Bacteria

Høiby, N., Friis, B., Jensen, K., Koch, C, Møller, N.E., Støvring, S. and Szaff, M. (Statens Seruminstitut, Departments of Clinical Microbiology at Rigshospitalet and Hvidovre Hospital, and Paediatric Department TG, Rigshospitalet, Copenhagen, Denmark). Antimicrobial chemotherapy in cystic fibrosis patients. Acta Paediatr Scand 1982; suppl 301: 75‐100. — Every effort should be undertaken to combat recurrent and chronic bacterial respiratory tract infections in patients with cystic fibrosis because infections are the main pathogenetic factors of lung damage in these patients. The principles and antibiotics used to treat bacterial infections in the Danish Cystic Fibrosis centre are outlined. The chemotherapy is based on microbiological diagnosis of secretions from the lower respiratory tract. S. aureus infections are efficiently treated with oral fusidic acid in combination with isoxazolyl penicillins or rifampicin in case of penicillin allergy or methicillin‐resistant S. aureus. H. influenzae infections are treated efficiently with oral pivampicillin or amoxicillin or with erythromycin sometimes in combination with rifampicin in case of penicillin allergy or ampicillin‐resistant H. influenzae. As a result of the efficient chemotherapy S. aureus and H. influenzae infections are now minor problems generally not related to prognosis of cystic fibrosis patients. Chronic P. aeruginosa infections are treated regularly four times per year with intravenous anti‐pseudomonas β‐lactam an...